CLEVELAND -- Corey Kluber lost for the first time since July 3 after Marwin Gonzalez connected for a three-run homer off Clevelands ace in the second inning, leading the Houston Astros over the Indians 4-3 on Tuesday night.Kluber (15-9) had won his previous seven decisions, a span during which he dominated the way he did while winning the Cy Young Award in 2014. But the right-hander had a bad sequence of six batters against the Astros, who have won the first two of four games between the playoff contenders.Gonzalez added two doubles for Houston, a major league-best 13-4 since Aug. 19.Reliever James Hoyt (1-0) struck out two in 1 1/3 innings for his first major league win. The 29-year-old rookie replaced Brad Peacock, who was called up to replace an injured Dallas Keuchel and made his first start since April 14, 2015.Carlos Santana homered in the eighth off Luke Gregerson to pull Cleveland within 4-2. The Indians scored an unearned run in the ninth and got the tying run to second before Ken Giles, Houstons fifth reliever, recorded his ninth save.The Indians, who have led the AL Central for 95 consecutive days, lost for just the second time in eight games.Kluber has been a big reason why the Indians have stayed on top of their division. The unflappable 30-year-old had not lost in over two months, and whenever his team needed a big outing, Kluber delivered. He was 7-0 with a 1.94 ERA in 11 starts since losing to Toronto in July.An uncharacteristic run hurt Kluber in the second.After getting two outs, he walked Evan Gattis and Colby Rasmus before quickly getting ahead 0-2 on Gonzalez. Kluber tried to sneak a curveball past Houstons first baseman, but he left it over the plate and Gonzalez drove it into the seats in right for his 12th homer to put the Astros up 3-0.The Indians, who couldnt score on Peacock in the first despite opening with a single and double, got a run back in the second on Tyler Naquins RBI groundout.Houston went ahead 4-1 in the third on Alex Bregmans RBI triple single off Kluber, who settled in and retired 15 of 17 before leaving after seven. He finished with nine strikeouts.Cleveland missed its chance to do early damage on Peacock, who worked out of the initial jam and gave the Astros all they could ask for in 3 2/3 innings.An injury to Keuchel prevented the game from being a matchup of former Cy Young winners. The left-hander was sent back to Houston with shoulder inflammation, a significant setback to the clubs wild-card chances.TRAINERS ROOMAstros: Manager A.J. Hinch said there was nothing new to report on Keuchel, who is expected to speak with the media Friday when the Astros begin a three-game series with the Cubs.Indians: C Yan Gomes (separated shoulder) is scheduled to be catching minor league games on his rehab assignment this weekend. Gomes, who has been on the disabled list since July 18, threw to bases Tuesday and will DH on Wednesday for Triple-A Columbus. He is eligible to be activated on Sept 16.UP NEXTAstros: RHP Doug Fister looks to bounce back after being tagged for seven runs and 10 hits in 3 2/3 innings against Texas on Sept. 2.Indians: RHP Carlos Carrasco, who struck out 11 and pitched 7 1/3 shutout innings in his last outing, starts for the fifth time in his career against Houston. Carrasco is 2-1 with a 2.05 ERA against the Astros. Harmon Killebrew Jersey . The 25-year-old Japanese star has officially been posted by his club team, the Rakuten Golden Eagles. Joe Mauer Jersey . 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This is Misbahs fifth-century after turning 40, all have come as captain; no captain scored more than three centuries after 40.8Centuries for Misbah as captain in Tests, which is the most by a Pakistan captain. He went past Inzamam-ul-Haqs seven centuries as captain. Misbah had scored only two centuries as non-captain in 33 innings compared to eight hundreds in 74 innings as captain.7Number of century stands between Misbah and Asad Shafiq for the fifth-wicket in Tests - the most by any pair. They went past Ricky Ponting and Steve Waugh who had shared six such stands for the fifth-wicket. The 148-run stand in this innings is Pakistans fourth-highest for any wicket in Tests at Lords.139.13Misbahs strike rate against Moeen Ali at the end of the first day. Misbah made 32 runs off 23 balls against Moeen hitting seven fours. 24 of those runs came behind the wicket - 12 on each side with three fours each. Against other batsmen, Moeen conceded 14 runs in 19 balls. Misbah scored 41 off Steven Finns 50 deliveries to him. Misbah, therefore, scored 73 runs off these two bowlers at a strike rate of 100 and 37 runs off the other bowlers at a strike rate of 34.90.13Number of fours hit by Misbah behind the wicket, out of the 18 fours by the end of first days play. He scored 63 out of the 110 runs behind the wicket - 29 runs on the off-side and 34 on the leg-side.3Number of Pakistan captains who scored a century in their maiden Test innings in England, including Misbah. The first two were: Hanif Mohammad (187*), also at Lords, in 1967 and Javed Miandad (153*) at Edgbaston in 1992. Unlike Misbah, they had played Tests in England before doing that as a captain. Misbah is only the fifth player to play his first Test innings in England as a captain and also score a century. Thee others being Graeme Smith, Alan Melville, Duleep Mendis and Angelo Mathews.dddddddddddd6The previous highest score by a Pakistan player in his maiden Test innings at Lords, by Asif Iqbal who scored those runs at No. 9 in 1967. Misbah has scored a century in his maiden Test innings here. Two Pakistan batsmen, Javed Burki and Nasim-ul-Ghani, made centuries (both made 101) in their first Test at Lords, in 1962, in their teams second innings. Shafiq, who is also playing in England for the first time, made 73 which is joint fourth-highest by a Pakistan player in his maiden Test innings at Lords.0Number of four-wicket hauls for Chris Woakes in Tests, before this. He took 4 for 45 by the end of first dayss play - his first such haul in career of nine Tests. His previous best figures were 3 for 9 against Sri Lanka in Durham earlier this year.7Number of consecutive Tests for Pakistan outside UAE where their openers have failed to score a fifty in the first innings of the match, which includes the first innings of this Test as well. The last fifty-plus score by an Pakistan opener in the first innings of an away Test was Mohammad Hafeezs 196 at the SSC in Colombo in 2012. Since then, in 14 innings there have been seven single-digit scores by them with highest of 42.6Number of times Younis Khan has been dismissed by Stuart Broad in seven Tests, which is the most by any England bowler since Broads debut. In this period, all the other England bowlers combined have dismissed Younis only six times. Overall, Younis has never got out more than three times to any other England bowler.6Number of visiting captains to score a century at Lords batting at No. 5 or lower. The only other captain to do so in the last 25 years is Angelo Mathews in 2014 who was also playing in England for the first time. Five of those six captains to do that have been from Asia; Garry Sobers is the only non-Asian. ' ' '